Preparation and physical‐biological characterization on titanium doped fluorophosphate nanobioglass: Bone implants

Abstract In bone tissue repair, metallic implants like screws, pins, plates, stents are considered as boon for patients but it has the disadvantage of being a foreign body and can never get absorbed or converted to bone. These serve purpose often temporarily, fails attain mechanical, elastic properties near that normal human bones. To circumvent these drawbacks, preparation nanobioglasses having titanium different proportions fluoride using melt quenching method is reported. The physical, thermal, materials were characterized by their densities, thermal transitions, moduli ultrasonic study. in vitro degradation bioactivity assessed immersion simulated fluid (SBF). hydroxyapatite(HAp) formation was variation pH over 21 days its presence confirmed FTIR, XRD, SEM, EDS. Human osteo sarcoma MG‐63(ATCC‐1427), SAOS‐2(ATCC‐85), gastric adenocarcinoma (AGS)(ATCC‐1739) cell lines used evaluate cytotoxicity bioglasses MTT assay. biological efficiency doped fluorophosphate enhancing capacity ionic dissolution products enhance osteocalcin ALP activity. phosphate‐based with possesses strength nearer bone, higher bonding ability rate biodegradation equaling than commercially available bioglass.